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A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Valsartan and Sacubitril, in its pure form as well as in tablet dosage form. Chromatography was carried out on an Sunfire C18 (4.6×250mm) 5µ column using a mixture of Water and Acetonitrile (60:40% v/v) as the mobile phase at a flow rate of 0.9ml/min, the detection was carried out at 220nm. The retention time of the Sacubitril and Valsartan was 3.0, 3.8±0.02min respectively. The method produce linear responses in the concentration range of 5-25µg/ml of Sacubitril and 75-375µg/ml of Valsartan. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.

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D. Hariprasad, Ch. Sunitha, & L.Harikiran. (2024). Validated rp-hplc method for simultaneous estimation of valsartan and sacubitril in bulk and tablet dosage form. International Journal of Intellectual Advancements and Research in Engineering Computations, 12(2), 47–57. Retrieved from